A targeted, minimally invasive treatment option
Botulinum toxin (commonly known as Botox) is a precise, muscle-based treatment used to improve eye alignment and reduce double vision in selected patients with adult strabismus.
Unlike surgery, it does not permanently alter the eye muscles. Instead, it temporarily weakens a specific muscle to allow the eyes to realign.
Is Botox a new or experimental treatment?
No — and this is a common misconception. Botulinum toxin has been used in the treatment of strabismus for over 40 years.
It was first introduced for strabismus in the 1970s, and importantly:
- It has been used routinely at Moorfields Eye Hospital since 1982
- It received FDA approval in 1989 for strabismus and related conditions
- It has been used widely across the UK, United States and globally ever since.
In Australia, botulinum toxin has been TGA-approved since 1999, including for strabismus-related indications
Why Botox was developed for strabismus
Botulinum toxin was not originally designed as a cosmetic treatment.
It was developed specifically to address a key clinical problem:
how to temporarily weaken an eye muscle without surgery
This made it particularly useful in:
- early or evolving strabismus
- nerve palsies
- patients with unstable measurements
- situations where surgery needed to be delayed or avoided
As a result, it became an important tool in major centres such as Moorfields and has remained part of standard strabismus management worldwide. Dr Shanel Sharma learnt how to do Botox as a treatment for Strabismus when undertaking her fellowship at Moorfields and the Western Eye Hospitals in London in 2010-2011.
How Botox works in strabismus
Each eye moves because of a balance between opposing muscles.
In strabismus, that balance between the muscles is disrupted.
Botulinum toxin works by:
- temporarily weakening an overacting muscle
- allowing the opposing muscle to rebalance eye position
- improving alignment and reducing double vision.
The injection is delivered directly into the eye muscle, usually with EMG guidance for precision. This is undertaken in the clinic and does not require Hospital admission.
What to expect after treatment
The timeline is important.
- No immediate effect (first 24–48 hours)
- Onset of action: 2–3 days
- Peak effect: ~2 weeks
- Duration: typically 3–4 months
- With the first few injections – the dosing is being determined for your eyes- so early follow up appointments at 2 weeks and top up injections are sometimes required.
“In approximately 5% of patients, ocular alignment persists beyond the duration of Botox. This likely reflects the presence of functional binocular pathways, enabling the visual system to maintain alignment once the eyes are restored to a controllable position.”
This is more likely if:
- binocular vision is still present
- the deviation is relatively recent
- the brain can re-establish fusion
Advantages of Botox
Botox has several practical advantages:
- minimally invasive (no incisions)
- rapid recovery
- reversible
- can be repeated
- useful in evolving or uncertain cases
For some patients, it allows earlier return to work and normal function, especially when diplopia is disabling.
Limitations and risks
However, Botox is not risk-free.
Common temporary effects include:
- droopy eyelid (ptosis) – approx 5%
- temporary overcorrection
- transient double vision in a different direction
These effects usually resolve as the toxin wears off.
Importantly: Most patients require repeat injections for ongoing control.